Human Leukocyte Antigen (HLA) part 73

hla protein 1

 

Hepatitis C Virus (HCV)

HLA associations with respect to hepatitis B virus and HCV infection susceptibility, protection, disease severity, interferon treatment  response and response to vaccination have been intensively investigated across the global population. The associations between HLA class I antigens and the outcome of HCV infection are are extensively investegated in different ethnic populations, and the reported associations showed ethnic and geographical differences sometimes with contradictory results. In the same time, there is a striking concordance between several of the HLA alleles associated with clearance   in both HIV and HCV infection including, in particular, HLA-B27. Other associations with HLA-B57 and HLA B08DR3 are less consistent  and may relate to differences in viral sequences in certain subpopulations.

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