Human Leukocyte Antigen (HLA) part 63

hla protein 1

 

HLA AND INFECTIOUS DISEASES

For an efficient  immune response to a pathogen to occur, HLA molecules must bind peptides derived from microbial proteins and the T cell repertoir must include clones that can be  activated by such HLA-bound peptides. Non-fulfilment of either of these requirements may render a person carrying a particular combination of HLA alleles more susceptible to a particular combination of HLA alleles more susceptible to a particular infectious disease than one who has a different  combination of alleles.

 

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