Human Leukocyte Antigen (HLA) part 60

hla protein 1

 

Among autoimmune disease, narcolepsy is uniquely positioned to demonstrate molecular mimicry in humans. First, narcolepsy occurs nearly exclusively in individuals with DQB1*0602. Second, a specific association  with the T receptor cell-α locus also confers an increased risk, indicating a crucial role for specific J segments of T cell receptor-α in the “immunological synapse” of narcolepsy.

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