Human Leukocyte Antigen (HLA) part 54

hla protein 1

 

Combined HLA class 1 and II deficiency where a significant reduction in the surface expression of HLA class I molecules  is associated with a lack of expression  of  HLA class II molecules. As in type II bare less lymphocyte, the resulting absence of humoral and cellular immune responses produces extreme susceptibility to viral, bacterial and parasitic infections early in life. The reduced expression of HLA class I molecules seems to be  a direct consequence of the mutations of the regulatory factor X  complex, which regulates the transcription of HLA class II genes. Indeed, the promoters of the genes of the heavy chains  of HLA class I molecules and β2  contain binding motifs  for several subunits of the regulatory factor X complex. These transcription factors thus may also play  a role in the transactivation of the genes of HLA class I molecules.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s