Human Leukocyte Antigen (HLA) part 53

hla protein 1

 

Atypical HLA class I deficiencies  are characterized by less severe reduction in surface expression of HLA class I molecules (approximately tenfold). It is called atypical due to  absence of clinical symptoms, and if present, it will be transient or moderate. It includes very heterogenous group due to  heterogenous molecular defects that are present  in this type. Patient with atypical HLA class I deficiency  will have a homozygous  HLA genotype and evidence of a transporter associated with antigent processing  2 deficiency. Thus transporter associated with antigen deficiency may lead to variably severe reductions in the surface levels of HLA class I molecules.

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