Human Leukocyte Antigen (HLA) part 47

hla protein 1


Seeking better answers to the question of HLA-disease association, de Almeida and Holoshitz have recently put forward a heterodox, Major histocompatibility  complex cusp theory at the focus of this theory is  a polymorphic region on HLA molecules whose tri-dimensional cusp like shape appears to have been  preserved in the entire major histocompatibilty complex family.  The theory proposes that the major histocompatibility complex codes for allele-specific ligands in the cusp region, which interact with non HLA-receptors and activate various pathway. Aberrations in those pathways could cause HLA-associated disease.


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