Human Leukocyte Antigen (HLA) part 32

hla protein 1

 

The peptide-binding structure consist of  a membrane-distal groove formed by two anti pararel α-helices overlaying and eight-strand  ß-sheets. In the case of HLA class I, the groove  corresponds to a contiguous amino acid sequence formed by the N-terminal region of the single HLA-encoded subunit,  or heavy chain, while for HLA class II, it is formed  by the juxtaposition of the N-terminal regions of two HLA-encoded α- and β- chains. A significant difference  is that for HLA class I the peptide is confined by binding groove interactions at both the N- and C-termini while for HLA class II, each end of the peptide can overhang the binding groove.

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