Human Leukocyte Antigen (HLA) part 7

hla protein 1

 

Exposure to another person’s HLA antigens may also induce alloactivation of T lymphocytes. Two general pathways of T-cell alloactivation have been recognized in transplant immunity.

The direct pathway refers to the alloreactive responses of recipient T cells to donor APC expressing incompatible HLA antigens. It provides a powerful mechanism of T-cell alloactivations.

In the indirect pathway, allogenic HLA antigens are released from donor cells, then taken up and processed (through the exogenous pathway) by recipient APC, and presented to recipient T cells as allopeptides bound to self-HLA  molecules

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