Dialysate composition – GLUCOSE

dialysis machine

 

Hemodialysate solutions often contain high concentrations of glucose (up to 200 mg/dl). The historical reasons for the addition of glucose to the dialysate including following:

  • enhancing ultrafiltration
  • minimization of nutritional (caloric) loses during dialysis

Recent evidence suggest that exposure to high levels of glucose may be proinflammatory and their use should be re-examined. Dialysate glucose concentrations  of 100 mg/dl are likely to be safe. Higher values may be predispose to the metabolic syndrome. Glucose free dialysate may be  beneficial metabolically and posibly less inflammatory. However, glucose-free dialysate may be associated with hypoglicemia, particularly  in poorly nourished patients, insulin-requiring diabetics or in acute hemodialysis settings

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