Clinical situation where is eGFR results may be unreliable and/or misleading

Kidney cartoon 3

 

Clinical situation where is eGFR results may be unreliable and/or misleading:

  • Acute changes in kidney function (e.g. acute kidney injury)
  • People on dialysis
  • Recent consumption of cooked meat (consider re-assesment when the individual has fasted or specifically avoided a cooked meat meal within 4 hours of blood sampling)
  • Exceptional dietary intake  (e.g. vegetarian diet, high protein diet, creatine supplements)
  • Extremes of body size
  • Diseases of skeletal muscle, paraplegia, or amputees (may  overestimate eGFR)
  • High muscle mass (may under estimate eGFR)
  • Severe liver disease present
  • eGFR values above 90 ml/min/1.73m2
  • Drugs interacting with creatine excretion (e.g. fenofibrate, trimetroprim)
  • Pregnancy
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