Early detection of chronic kidney disease

Happy kidney character

 

Early detection of chronic kidney disease:

  • Increasing amounts of albumin in the urine correlate directly with an increased rate of progression to end stage kidney disease
  • eGFR (estimated glomerular filtration rate) correlates well with complications of chronic kidney disease and an increased risk of adverse outcomes such as cardiovascular morbidity and mortality
  • Early intervention with blood pressure reduction and use of ACE inhibitors (Angiotensin-conerting enzyme inhibitor) or ARB (Angiotensin II receptor blocker) can reduce progression and cardiovascular risk by up to 50% and may  also improve quality of life
  • Testing for chronic kidney disease should not be universal, but should be targeted and performed in individuals at increased risk of developing chronic kidney disease
  • Serum creatinine is an insensitive marker for detecting mild to moderate kidney disease – eGFR (estimated glomerular filtration rate) is the preferred test
  • 50% or more of kidney function can be lost before the serum creatinine rises above the upper limit of normal
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