Clinical use of stem cells in orthopaedics part 75

Stem cell 2

 

It is also highly recomended that treating physicians do not thrust aside the concomitant use of established measures until  stem cell tharapy is evidently proved worthy in terms of efficacy and cost.

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Clinical use of stem cells in orthopaedics part 74

Stem cell 2

 

Precise use of definitions and nomenclaturs regarding cell sources and cell types is mandatory as well as differentiation between culture expanded cells  and native cells, and between autologous and allogeneic sources. It will also help to have a basic knowledge on the use and availability of methods for quantification and characterisation of the cells and the efficiency of harvest, processing and delivering procedures.

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Clinical use of stem cells in orthopaedics part 73

Stem cell 2

As for any modality of clinical medicine, stem cell treatment requires an understanding of the underlying pathophysiology of the disease. It is imperative that clinicians who adopt these new strategies into their practices posssess a good understanding of the natural course of the targeted disease. It is also important for treating clinicians to have an enhanced understanding of different cell sources, with analysis of the reported population of native stem and progenitor cells.

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Clinical use of stem cells in orthopaedics part 72

Stem cell 2

 

Cell therapy for osteoarthritis holds greater potential for stem cell therapy because of its  larger pool of patients and irreversible nature  of disease progression. In addition to a need for controlled studies to prove long-term efficacy, its mode of action should be defined on whether the injected cells  actually differentiate into articular chondrocytes or merely exert paracrine effects. Paucity of clinical reports makes it difficult to provide a perspective on the stem cell therapy for tendon disease. Further studies are necessary which will corroborate the results of a few currently available reports.

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Clinical use of stem cells in orthopaedics part 71

Stem cell 2

 

Further advancement  in tissue engineering will facilitate the application of stem cell treatment for large long-bone defect. much preclinical investigation had been performed to provide a rational for stem cell implantation for osteochondral defects. while promising results  have been reported from sporadic clinical reports, an aggrement  on the number of cells and suitable  carrier materials is desired at this time that will allow a prospective  clinical study of large scale.

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Clinical use of stem cells in orthopaedics part 70

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Of bone regeneration, osteonecrosis of femoral head  has been the greatest focus for cell therapy . However, most reported studies were uncontrolled and used bone marrow aspirate concentrate. Prospective controlled studies using mesenchymal stem cells have recently been reported. More evidence will be accumulated to prove the effectiveness of  stem cell treatment in arresting the progression  of the disease. Large long-bone defect is the entity where regenerative medicine is most needed. Because of challenging nature of constructing a viable cell-scaffold composite,, clinical application of stem cells is still in its incipient stage

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Clinical use of stem cells in orthopaedics part 69

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The application of regenerative medicine for musculoskeletal disorders has become widespread, despite   the relative lack of critical evidence supporting its efficacy. To date, the literature supporting stem cell-based therapies comprises mostly case reports or case series with small number of phase I-III clinical studies. Despite the want of strong clinical evidence, the use of these therapies continues to expand due to the need for novel, minimally invasive therapies to treat conditions. Therefore, high-quality evidence, including from randomised clinical trials, is necessary to define the role of cell-based therapies in the treatment of musculoskeletal disorders

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